Caris Life Sciences: Material Modification To Rights Of Security Holders, Amendments To Articles Of Incorporation Or Bylaws; Change In Fiscal Year, Financial Statements And Exhibits

Item 3.03 Material Modification to Rights of Security Holders.The information set forth under Item 5.03 of this Current Report on Form 8-K is incorporated into this Item 3.03 by reference.Item 5.03 Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year. On October 30, 2025, the Board of Directors of Caris Life Sciences, Inc. (the “Company”) approved and adopted an amendment and restatement of the Company’s bylaws (the “Bylaws”) to provide that a shareholder (defined, in accordance with the Texas Business Organizations Code, to include a group of shareholders acting together) must beneficially own, at the time the derivative proceeding is instituted, a number of shares of common stock equal to at least three percent of the Company’s outstanding shares to institute or maintain a derivative proceeding. The foregoing description of the amendment and restatement of the Bylaws is qualified in its entirety by reference to the full text of the Bylaws, a copy of which is attached hereto as Exhibit 3.1 and incorporated herein by reference. Item 9.01 Financial Statements and Exhibits.(d) Exhibits Exhibit No.Description3.1Amended and Restated Bylaws of Caris Life Sciences, Inc.104Cover Page Interactive Data File (embedded within the Inline XBRL document).SIGNATURESPursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.Date: October 30, 2025CARIS LIFE SCIENCES, INC.By:/s/ Luke PowerName:Luke PowerTitle:Senior Vice President, Chief Financial Officer and Chief Accounting Officer

Caris Life Sciences: Material Modification To Rights Of Security Holders, Amendments To Articles Of Incorporation Or Bylaws; Change In Fiscal Year, Financial Statements And Exhibits

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